2 are scientific papers...one is a testimonial :D
The first one...
A Preliminary Ecotoxicity Study of Pharmaceuticals in the Marine Environment
Authors: Mei Fun Choong, Amy1; Lay-Ming Teo, Serena1; Lene Leow, Jo2; Ling Koh, Hwee2; Chi Lui Ho, Paul2
Source: Journal of Toxicology and Environmental Health Part A, Volume 69, Number 21, November 1 2006, pp. 1959-1970(12)
Publisher: Taylor and Francis Ltd
Abstract:
Environmental fates and effects of pharmaceuticals in the aquatic environment have been the focus of recent research in environmental ecotoxicology. Worldwide studies of common over-the-counter pharmaceuticals have reported detectable levels in the aquatic environment, but there are few studies examining impacts on marine habitats. These drugs can affect the functions of various vertebrates and invertebrates. The stability of two pharmaceuticals, cyclizine (CYC) and prochlorperazine (PCZ), in seawater was examined under light and dark conditions, as well as the toxicity of these compounds to larvae of the barnacle Balanus amphitrite, which is a cosmopolitan marine organism found in most of the world's oceans. CYC was very stable under all the tested conditions. On the other hand, PCZ degraded in light but not in the dark, and was more stable in seawater than fresh water. For the barnacle larvae, the LC 50 of prochlorperazine was 0.93 μg/ml and the LC 50 for CYC was approximately 0.04 μg/ml.
Document Type: Research article
DOI: 10.1080/15287390600751371
Affiliations: 1: Tropical Marine Science Institute, National University of Singapore, Singapore 2: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
The second one...still in process of publication :P
Quantitative structure–activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase
Jo-Lene Leow1, Rudi Baron2, Patrick J. Casey2 and Mei-Lin Go1 ,
1:Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
2:Department of Pharmacology and Cancer Biology, Duke University Medical Centre, Durham, NC 27710, USA
Received 18 July 2006; revised 26 October 2006; accepted 13 November 2006. Available online 15 November 2006.
Abstract
A QSAR is developed for the isoprenylcysteine carboxyl methyltransferase (ICMT) inhibitory activities of a series of indoloacetamides (n = 72) that are structurally related to cysmethynil, a selective ICMT inhibitor. Multivariate analytical tools (principal component analysis (PCA) and projection to latent structures (PLS)), multi-linear regression (MLR) and comparative molecular field analysis (CoMFA) are used to develop a suitably predictive model for the purpose of optimizing and identifying members with more potent inhibitory activity. The resulting model shows that good activity is determined largely by the characteristics of the substituent attached to the indole nitrogen, which should be a lipophilic residue with fairly wide dimensions. In contrast, the substituted phenyl ring attached to the indole ring must be of limited dimensions and lipophilicity.
Article still in press in BMCL (Bioorganic & Medicinal Chemistry Letters) ;)
Yippee....that's like a lot of CPE points for me...hehe...
The third one is a testimonial..hehe
From here...
If u live in the modern world...I'm sure u are under plenty of free radical attack too...from the sun, the polluted air, radiation from handphones/computers, stress or just from exchanging oxygen into carbon dioxide :P
So would u like to try a bottle of g3 or a box of Lifepak? Dun wait till some chronic diseases or worse still cancer develop hor :P
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